After impregnating a scientist, the newborn Chestburster escaped into an airduct to mature. In a Weyland-Yutani research facility, a untainted captive Facehugger managed to break free from its stasis tube. Despite fighting bravely, the Jungle Hunter was overpowered by the massive Predator and was beheaded just after sending a distress signal to his Clan Leader. To test their newly controlled Xenomorph, the Berserker thrown a captured Jungle Hunter Predator in the Temple Arena, however as things didn't go as he thought, the Berserker enter the arena. Out of desperation the Queen called for Drones to protect her but they were quickly slaughtered, in the end the Queen was captured by the Super Predators and their plan to control them can began. One of them get headbitten until the Berserker Super Predator end the fight by incapaciting her with his plasmacaster. In the undergrounds of a Predator temple on LV-412, Super Predators are seen struggling with an Alien Queen.

Similarly to the Alien campaign of Aliens versus Predator 2, Alien players start off as a Facehugger and must find a host to impregnate so the player may become a Chestburster and eventually grow into an adult Alien The game is in the third-person perspective and features the Super Predators as the antagonists of the storyline. 3.18 Alien Mission 10 - Berserker Arena.3.16 Predator Mission 8 - Temple Descent.3.15 Alien Mission 8 - Loading Facility.3.9 Predator Mission 5 - Restricted Facility.3.7 Predator Mission 4 - Weapons Research.3.6 Alien Mission 3 - The Living Weapon.3.5 Alien Mission 2 - Facehugger at Large.3.1 Predator Mission 1 - Proving Ground.

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